Exact constitutaional classification is especially important in Sasang Constitutional Medicine. Therefore, most studies on the Sasnag Constitutional medicine have been focused on how accurately to classify Sasang Constitution. Recently, there
have
been
reported on the studies about relationship between genetic polymorphism and Sasang Constitution.
The purpose of this study is to investigate whether there is any correlation between Sasang Constitution and HLA type.
Polymorphism of HLA genes have been known to be important role in transplantation, autoimmune diseas, immune response against infection. This study was concentrate on a relationship of HLA-A, -C,-DR, and -DQ types with Sasang Costitution. Results
are as
following.
1. In the case of HLA-A, there was no significant difference. Only HLA-A*31 has a tendency which Soyangin is less frequent than Soeumin and Taeumin.
2. In the case of HLA-C, there was significant difference between Sasang Constitutiona and HLA type. In persons having HLA-C*04 allele, Taeumin is more frequent than Soyangin and Soeumin. On the other hand, Soyangin is more frequent than Taeumin
and
Soeumin in HLA-C*07 allele. HLA-C*14 has a tendency which Soeumin is more frequent than Soyangin and Taeumin.
3. In the case of HLA-DR type and HLA-DQ type, there was no significant difference among Sansang Constitution.
On the study of correlation between Sasang Constitution and HLA type, there was littel statistical significance and tendency. This study was the first try about presentation of frequency on the HLA alleles corresponding with Sasang Constitution.
I
think
that more study on the relationship between HLA gene and Sasang Constitution is necessary by method of large case research and various statistical analysis.
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